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Download PDF by Michael E. Aulton BPharm PhD FAAPS MRPharmS, Kevin Taylor: Pharmaceutics: The Science of Dosage Form Design

By Michael E. Aulton BPharm PhD FAAPS MRPharmS, Kevin Taylor

ISBN-10: 0443055173

ISBN-13: 9780443055171

A finished textbook protecting the layout of dosage varieties and all elements of drug supply platforms. 'Pharmaceutics' in its broadest experience is the 'art of the apothecary' or, only, pharmaceutical arrangements. It is still a various topic within the pharmacy curriculum, encompassing layout of gear, their manufacture, and the removing of micro-organisms from the goods. This books encompasses all these parts and can pay specific recognition to the layout of dosage types and their manufacture.

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Extra resources for Pharmaceutics: The Science of Dosage Form Design

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Diffusion may be defined as the spontaneous transference of a component from a region in the system where it has a high chemical potential into one where its chemical potential is lower. Although such a gradient in chemical potential provides the driving force for diffusion, the laws that describe this phenomenon are usually expressed in terms of concentration gradients, for example Pick's first law, which is discussed in Chapter 2. The most common explanation of the mechanism of diffusion in solution is based on the lattice theory of the structure of liquids.

The velocity, which will be almost zero at the surface, increases with increasing distance from the surface until the bulk of the fluid is reached and the velocity becomes constant. The region over which differences in velocity are observed is referred to as the boundary layer. Its depth is dependent upon the viscosity of the fluid and the rate of flow in the bulk fluid: high viscosity and a low flow rate would result in a thick boundary layer, which will become thinner as either the viscosity falls or the flow rate is increased.

This chapter describes rheological behaviour and techniques of measurement, and will form a basis for the applied studies described in later chapters. vehicles 57 Deflocculated particles in non-Newtonian vehicles 57 Flocculated particles in Newtonian vehicles 58 Flocculated particles in non-Newtonian vehicles 58 Emulsions 58 The effect of rheological properties on bioavailability 58 Bibliography 58 NEWTONIAN FLUIDS Viscosity coefficients for Newtonian fluids Dynamic viscosity The definition of viscosity was put on a quantitative basis by Newton, who was the first to realize that the 41 SCIENTIFIC PRINCIPLES OF DOSAGE FORM DESIGN rate of flow (y) was directly related to the applied stress (cr): the constant of proportionality is the coefficient of dynamic viscosity, (17), more usually referred to simply as the viscosity.

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Pharmaceutics: The Science of Dosage Form Design by Michael E. Aulton BPharm PhD FAAPS MRPharmS, Kevin Taylor


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